[1]查刘生,刘紫微.生物分子识别响应性水凝胶及其智能给药系统[J].智能系统学报,2007,2(6):38-47.
　ZHA Liu-sheng,LIU Zi-wei.Biomolecular recognition in responsive hydrogels and their use as intelligent drug delivery systems[J].CAAI Transactions on Intelligent Systems,2007,2(6):38-47.
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生物分子识别响应性水凝胶及其智能给药系统

《智能系统学报》[ISSN 1673-4785/CN 23-1538/TP] 卷: 2 期数: 2007年第6期 页码: 38-47 栏目: 学术论文—智能系统 出版日期: 2007-12-25
Title:
Biomolecular recognition in responsive hydrogels and  their use as intelligent drug delivery systems
文章编号:
1673-4785(2007)06-0038-10
作者:
查刘生1，2，刘紫微1
1.东华大学 纤维材料改性国家重点实验室，上海201620；
2.东华大学分析测试中心，上海201620
Author(s):
ZHA Liu-sheng1,2, LIU Zi-wei1
1.State Key Laboratory for Modification of Chemical Fibers and Polym er Materials，Donghua University, Shanghai 201620, China;
 2.Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China
关键词:
智能水凝胶; 生物分子识别; 智能给药系统; 刺激响应性
Keywords:
intelligent hydrogels;  biomolecular recognition;  intelligent drug delivery syste m;  stimulative response
分类号:
Q811
文献标志码:
A
摘要:
生物分子识别响应性水凝胶是模拟生命活动过程中的分子识别现象，能识别特定生物分子而产生刺激响应性的智能高分子材料.用它构筑的智能系统类似于具有反馈和平衡功能的生物系统，在生物工程和生物医学领域有非常诱人的应用前景.对能识别特定生物分子，如葡萄糖、酶、抗原、核酸等，产生刺激响应的智能水凝胶的制备及其在智能给药系统中的应用研究情况进行了详细介绍.这些内容有助于更好地理解生物分子识别响应性水凝胶的结构和功能，另外也为发展新型智能给药系统提供了很好的思路.
Abstract:
Biomolecule recognition responsive hydrogels are the intelligent polymer materia ls which can recognize specific biomolecules and respond to them mimicking the m oleculerecognizing process of life activity. The intelligent systems fabricate d from the hydrogels resemble the biological systems with feedback and equilibriu m functions, and they have a great deal of potential applications in the fields of bioengineering and biomedicine. In this paper, we give a deta iled overview of current research in the preparation of intelligent hydrogels th at respond to specific molecules, such as glucose, enzymes, antigens, nucleic ac id, etc. The application of these hydrogels in intelligent drug delivery system s is also introduced. Then the paper explains the relationship between the struc tures and functions of biomolecular recognition in responsive hydrogels, giving a good basis for the development of new types of intelligent drug delivery syste ms.
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备注/Memo

收稿日期：2007-03-02.
基金项目：国家自然科学基金资助项目（50573009）
作者简介：
查刘生，男，1964年生，教授，博士生导师，主要研究方向为智能高分子材料及其智能系统.主持过国家科委地方重大科技攻关项目和国家自然科学基金面上项目，有4项成果通过省级鉴定，处于国内或国际领先水平，1项成果获省部级科技进步三等奖，申报国家发明专利1项，完成横向开发项目14项，发表论文50多篇，其中20多篇被 SCI收录. E-mail:lszha@dhu.edu.cn.
刘紫微，女，1981年生，硕士研究生，主要研究方向为生物分子识别响应性水凝胶. E-mail:ziweiliu@mail.dhu.edu.cn.

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